The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2) deacetylase as a potential drug target to counteract neurodegeneration. In the present study, we characterize SIRT2 inhibition activity of the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chen, Xiqun, Wales, Pauline, Quinti, Luisa, Zuo, Fuxing, Moniot, Sébastien, Herisson, Fanny, Rauf, Nazifa Abdul, Wang, Hua, Silverman, Richard B., Ayata, Cenk, Maxwell, Michelle M., Steegborn, Clemens, Schwarzschild, Michael A., Outeiro, Tiago F., Kazantsev, Aleksey G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301865/
https://ncbi.nlm.nih.gov/pubmed/25608039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116919
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