The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2) deacetylase as a potential drug target to counteract neurodegeneration. In the present study, we characterize SIRT2 inhibition activity of the...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Chen, Xiqun, Wales, Pauline, Quinti, Luisa, Zuo, Fuxing, Moniot, Sébastien, Herisson, Fanny, Rauf, Nazifa Abdul, Wang, Hua, Silverman, Richard B., Ayata, Cenk, Maxwell, Michelle M., Steegborn, Clemens, Schwarzschild, Michael A., Outeiro, Tiago F., Kazantsev, Aleksey G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301865/
https://ncbi.nlm.nih.gov/pubmed/25608039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116919
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