Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects

BACKGROUND: Aldosterone synthase inhibition provides the potential to attenuate both the mineralocorticoid receptor-dependent and independent actions of aldosterone. In vitro studies with recombinant human enzymes showed LCI699 to be a potent, reversible, competitive inhibitor of aldosterone synthas...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Transl Med
Huvudupphovsmän: Ménard, Joël, Rigel, Dean F, Watson, Catherine, Jeng, Arco Y, Fu, Fumin, Beil, Michael, Liu, Jing, Chen, Wei, Hu, Chii-Whei, Leung-Chu, Jennifer, LaSala, Daniel, Liang, Guiqing, Rebello, Sam, Zhang, Yiming, Dole, William P
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301837/
https://ncbi.nlm.nih.gov/pubmed/25491597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0340-9
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk