Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects

BACKGROUND: Aldosterone synthase inhibition provides the potential to attenuate both the mineralocorticoid receptor-dependent and independent actions of aldosterone. In vitro studies with recombinant human enzymes showed LCI699 to be a potent, reversible, competitive inhibitor of aldosterone synthas...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Ménard, Joël, Rigel, Dean F, Watson, Catherine, Jeng, Arco Y, Fu, Fumin, Beil, Michael, Liu, Jing, Chen, Wei, Hu, Chii-Whei, Leung-Chu, Jennifer, LaSala, Daniel, Liang, Guiqing, Rebello, Sam, Zhang, Yiming, Dole, William P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301837/
https://ncbi.nlm.nih.gov/pubmed/25491597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0340-9
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