Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na(+) in Wistar rats

In Wistar rats, increasing cerebrospinal fluid (CSF) Na(+) concentration ([Na(+)]) by intracerebroventricular (ICV) infusion of hypertonic saline causes sympathetic hyperactivity and hypertension that can be prevented by blockade of brain mineralocorticoid receptors (MR). To assess the role of aldos...

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Bibliographische Detailangaben
Hauptverfasser: Huang, Bing S., White, Roselyn A., Ahmad, Monir, Jeng, Arco Y., Leenen, Frans H. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2008
Schlagworte:
Neurohumoral Control of Cardiovascular Function
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494821/
https://ncbi.nlm.nih.gov/pubmed/18495825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.90352.2008
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