Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

[Image: see text] Aldosterone is a key signaling component of the renin-angiotensin-aldosterone system and as such has been shown to contribute to cardiovascular pathology such as hypertension and heart failure. Aldosterone synthase (CYP11B2) is responsible for the final three steps of aldosterone s...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Meredith, Erik L., Ksander, Gary, Monovich, Lauren G., Papillon, Julien P. N., Liu, Qian, Miranda, Karl, Morris, Patrick, Rao, Chang, Burgis, Robin, Capparelli, Michael, Hu, Qi-Ying, Singh, Alok, Rigel, Dean F., Jeng, Arco Y., Beil, Michael, Fu, Fumin, Hu, Chii-Whei, LaSala, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027133/
https://ncbi.nlm.nih.gov/pubmed/24900631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400324c
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados