Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

[Image: see text] Aldosterone is a key signaling component of the renin-angiotensin-aldosterone system and as such has been shown to contribute to cardiovascular pathology such as hypertension and heart failure. Aldosterone synthase (CYP11B2) is responsible for the final three steps of aldosterone s...

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Autori principali: Meredith, Erik L., Ksander, Gary, Monovich, Lauren G., Papillon, Julien P. N., Liu, Qian, Miranda, Karl, Morris, Patrick, Rao, Chang, Burgis, Robin, Capparelli, Michael, Hu, Qi-Ying, Singh, Alok, Rigel, Dean F., Jeng, Arco Y., Beil, Michael, Fu, Fumin, Hu, Chii-Whei, LaSala, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2013
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027133/
https://ncbi.nlm.nih.gov/pubmed/24900631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400324c
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