Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes

BACKGROUND: Cartilage is an avascular and aneural tissue. Chondrocytes thrive in this restricted environment of low oxygen tension and poor nutrient availability which has led to suggestions that hypoxia may be a protective mechanism against the development of osteoarthritis (OA). There is also a gr...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Musculoskelet Disord
Main Authors: Alvarez, Karl, de Andrés, María C, Takahashi, Atsushi, Oreffo, Richard O C
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301830/
https://ncbi.nlm.nih.gov/pubmed/25510649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-15-431
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