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K(v)11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical K(v)11.1 (hERG) inhibitors
BACKGROUND AND PURPOSE: Drug-induced arrhythmia due to blockade of the K(v)11.1 channel (also known as the hERG K(+) channel) is a frequent side effect. Previous studies have primarily focused on equilibrium parameters, i.e. affinity or potency, of drug candidates at the channel. The aim of this stu...
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| Publicat a: | Br J Pharmacol |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BlackWell Publishing Ltd
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301700/ https://ncbi.nlm.nih.gov/pubmed/25296617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12967 |
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