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K(v)11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical K(v)11.1 (hERG) inhibitors
BACKGROUND AND PURPOSE: Drug-induced arrhythmia due to blockade of the K(v)11.1 channel (also known as the hERG K(+) channel) is a frequent side effect. Previous studies have primarily focused on equilibrium parameters, i.e. affinity or potency, of drug candidates at the channel. The aim of this stu...
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| Vydáno v: | Br J Pharmacol |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BlackWell Publishing Ltd
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301700/ https://ncbi.nlm.nih.gov/pubmed/25296617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12967 |
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