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Pharmacological targeting of GSK3β confers protection against podocytopathy and proteinuria by desensitizing mitochondrial permeability transition

BACKGROUND AND PURPOSE: Mitochondrial dysfunction, triggered by mitochondria permeability transition (MPT), has been centrally implicated in the pathogenesis of podocytopathy and involves a multitude of cell signalling mechanisms, among which, glycogen synthase kinase (GSK) 3β has emerged as the int...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Br J Pharmacol
Main Authors: Wang, Zhen, Bao, Hui, Ge, Yan, Zhuang, Shougang, Peng, Ai, Gong, Rujun
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301697/
https://ncbi.nlm.nih.gov/pubmed/25262943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12952
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