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Pharmacological targeting of GSK3β confers protection against podocytopathy and proteinuria by desensitizing mitochondrial permeability transition

BACKGROUND AND PURPOSE: Mitochondrial dysfunction, triggered by mitochondria permeability transition (MPT), has been centrally implicated in the pathogenesis of podocytopathy and involves a multitude of cell signalling mechanisms, among which, glycogen synthase kinase (GSK) 3β has emerged as the int...

詳細記述

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書誌詳細
出版年:Br J Pharmacol
主要な著者: Wang, Zhen, Bao, Hui, Ge, Yan, Zhuang, Shougang, Peng, Ai, Gong, Rujun
フォーマット: Artigo
言語:Inglês
出版事項: BlackWell Publishing Ltd 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301697/
https://ncbi.nlm.nih.gov/pubmed/25262943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12952
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