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Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors
BACKGROUND AND PURPOSE: Histone deacetylase 6 (HDAC6) and silent information regulator 2 (SIRT2) control the dynamics of the microtubule network via their deacetylase activities. Tubulin polymerization promoting protein (TPPP/p25) enhances microtubule acetylation by its direct binding to HDAC6. Our...
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| 發表在: | Br J Pharmacol |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BlackWell Publishing Ltd
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301692/ https://ncbi.nlm.nih.gov/pubmed/25257800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12946 |
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