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Ionic mechanisms underlying the negative chronotropic action of propofol on sinoatrial node automaticity in guinea pig heart
BACKGROUND AND PURPOSE: Propofol is a widely used intravenous anaesthetic agent, but has undesirable cardiac side effects, including bradyarrhythmia and its severe form asystole. This study examined the ionic and cellular mechanisms underlying propofol-induced bradycardia. EXPERIMENTAL APPROACH: Sin...
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| Publicado en: | Br J Pharmacol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BlackWell Publishing Ltd
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301690/ https://ncbi.nlm.nih.gov/pubmed/25220338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12936 |
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