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Negative chronotropic actions of endothelin-1 on rabbit sinoatrial node pacemaker cells

1. The effects of endothelin-1 (ET-1) on sinoatrial (SA) node preparations of the rabbit heart were studied by means of whole-cell clamp techniques. 2. ET-1 at 1 nM slowed the spontaneous beating activity and rendered half of the cells quiescent. At a higher concentration of 10 nM, the slowing and c...

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Autors principals: Tanaka, Hideo, Habuchi, Yoshizumi, Yamamoto, Taku, Nishio, Manabu, Morikawa, Junichiro, Yoshimura, Manabu
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564927/
https://ncbi.nlm.nih.gov/pubmed/9313942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701370
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