Electrophysiological analysis of the negative chronotropic effect of endothelin-1 in rabbit sinoatrial node cells

1. Electrophysiological effects of endothelin-1 (ET-1) were studied in rabbit sinoatrial node (SAN) using conventional microelectrode and whole-cell voltage and current recordings. 2. In rabbit SAN, RT-PCR detected ET(A) endothelin receptor mRNA. ET−1 (100 nm) increased the cycle length of action po...

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Bibliographic Details
Main Authors: Ono, Kageyoshi, Masumiya, Haruko, Sakamoto, Aiji, Christé, Georges, Shijuku, Toshinori, Tanaka, Hikaru, Shigenobu, Koki, Ozaki, Yukihiro
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278974/
https://ncbi.nlm.nih.gov/pubmed/11731579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.00467.x
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