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Inhibitory effects of sevoflurane on pacemaking activity of sinoatrial node cells in guinea-pig heart

BACKGROUND AND PURPOSE: The volatile anaesthetic sevoflurane affects heart rate in clinical settings. The present study investigated the effect of sevoflurane on sinoatrial (SA) node automaticity and its underlying ionic mechanisms. EXPERIMENTAL APPROACH: Spontaneous action potentials and four ionic...

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Detalhes bibliográficos
Main Authors: Kojima, Akiko, Kitagawa, Hirotoshi, Omatsu-Kanbe, Mariko, Matsuura, Hiroshi, Nosaka, Shuichi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402776/
https://ncbi.nlm.nih.gov/pubmed/22356456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01914.x
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