Topical Herpes Simplex Virus 2 (HSV-2) Vaccination with Human Papillomavirus Vectors Expressing gB/gD Ectodomains Induces Genital-Tissue-Resident Memory CD8(+) T Cells and Reduces Genital Disease and Viral Shedding after HSV-2 Challenge

No herpes simplex virus 2 (HSV-2) vaccine has been licensed for use in humans. HSV-2 glycoproteins B (gB) and D (gD) are targets of neutralizing antibodies and T cells, but clinical trials involving intramuscular (i.m.) injection of HSV-2 gB and gD in adjuvants have not been effective. Here we evalu...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Çuburu, Nicolas, Wang, Kening, Goodman, Kyle N., Pang, Yuk Ying, Thompson, Cynthia D., Lowy, Douglas R., Cohen, Jeffrey I., Schiller, John T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301134/
https://ncbi.nlm.nih.gov/pubmed/25320297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02380-14
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