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A Herpes Simplex Virus 2 (HSV-2) gD Mutant Impaired for Neural Tropism Is Superior to an HSV-2 gD Subunit Vaccine To Protect Animals from Challenge with HSV-2

A recent phase 3 trial with soluble herpes simplex virus 2 (HSV-2) glycoprotein D (gD2t) in adjuvant failed to show protection against genital herpes. We postulated that live attenuated HSV-2 would provide more HSV antigens for induction of virus-specific antibodies and cellular immunity than would...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Wang, Kening, Goodman, Kyle N., Li, Daniel Y., Raffeld, Mark, Chavez, Mayra, Cohen, Jeffrey I.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702532/
https://ncbi.nlm.nih.gov/pubmed/26559846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01845-15
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