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A Selective NMR Probe to Monitor the Conformational Transition from Inactive to Active Kinase
[Image: see text] Kinases control many aspects of cellular signaling and are therefore therapeutic targets for numerous disease states. Monitoring the conformational changes that drive activation and inactivation of the catalytic kinase core is a challenging experimental problem due to the dynamic n...
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| Veröffentlicht in: | ACS Chem Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301085/ https://ncbi.nlm.nih.gov/pubmed/25248068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5004702 |
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