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The Transition Between Active and Inactive Conformations of Abl Kinase Studied by Rock Climbing and Milestoning
BACKGROUND: Kinases are a family of enzymes that catalyse the transfer of the ɤ-phosphate group from ATP to a protein’s residue. Malfunctioning kinases are involved in many health problems such as cardiovascular diseases, diabetes, and cancer. Kinases transitions between multiple conformations of in...
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| Veröffentlicht in: | Biochim Biophys Acta Gen Subj |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7012767/ https://ncbi.nlm.nih.gov/pubmed/31884066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2019.129508 |
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