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Achieving a Graded Immune Response: BTK Adopts Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts
Capturing the functionally relevant forms of dynamic, multidomain proteins is extremely challenging. BTK, a kinase essential for B and mast cell function, has stubbornly resisted crystallization in its full-length form. Here, NMR and HDX-MS show that BTK adopts a closed conformation in dynamic equil...
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| Veröffentlicht in: | Structure |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5629114/ https://ncbi.nlm.nih.gov/pubmed/28867612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.07.014 |
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