Llwytho...

Achieving a Graded Immune Response: BTK Adopts Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts

Capturing the functionally relevant forms of dynamic, multidomain proteins is extremely challenging. BTK, a kinase essential for B and mast cell function, has stubbornly resisted crystallization in its full-length form. Here, NMR and HDX-MS show that BTK adopts a closed conformation in dynamic equil...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Structure
Prif Awduron: Joseph, Raji E., Wales, Thomas E., Fulton, D. Bruce, Engen, John R., Andreotti, Amy H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629114/
https://ncbi.nlm.nih.gov/pubmed/28867612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.07.014
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