Mutations in HIV-1 Envelope That Enhance Entry with the Macaque CD4 Receptor Alter Antibody Recognition by Disrupting Quaternary Interactions within the Trimer

Chimeric simian immunodeficiency virus (SIV)/human immunodeficiency virus (HIV) (SHIV) infection of macaques is commonly used to model HIV type 1 (HIV-1) transmission and pathogenesis in humans. Despite the fact that SHIVs encode SIV antagonists of the known macaque host restriction factors, these v...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Boyd, David F., Peterson, Dylan, Haggarty, Beth S., Jordan, Andrea P. O., Hogan, Michael J., Goo, Leslie, Hoxie, James A., Overbaugh, Julie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300673/
https://ncbi.nlm.nih.gov/pubmed/25378497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02680-14
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