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Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5
Although Rhesus macaques are an important animal model for HIV-1 vaccine development research, most transmitted HIV-1 strains replicate poorly in macaque cells. A major genetic determinant of this species-specific restriction is a non-synonymous mutation in macaque CD4 that results in reduced HIV-1...
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| Publicado no: | Viruses |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7077290/ https://ncbi.nlm.nih.gov/pubmed/32098152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12020241 |
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