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Mapping mutational effects along the evolutionary landscape of HIV envelope

The immediate evolutionary space accessible to HIV is largely determined by how single amino acid mutations affect fitness. These mutational effects can shift as the virus evolves. However, the prevalence of such shifts in mutational effects remains unclear. Here, we quantify the effects on viral gr...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Haddox, Hugh K, Dingens, Adam S, Hilton, Sarah K, Overbaugh, Julie, Bloom, Jesse D
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910023/
https://ncbi.nlm.nih.gov/pubmed/29590010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34420
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