Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling

BACKGROUND: Many receptors function by binding to multiple ligands, each eliciting a distinct biological output. The extracellular domain of the human prolactin receptor (hPRL-R) uses an identical epitope to bind to both prolactin (hPRL) and growth hormone (hGH), yet little is known about how each h...

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Vydáno v:Cell Commun Signal
Hlavní autoři: Rizk, Shahir S, Kouadio, Jean-Louis K, Szymborska, Anna, Duguid, Erica M, Mukherjee, Somnath, Zheng, Jiamao, Clevenger, Charles V, Kossiakoff, Anthony A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300558/
https://ncbi.nlm.nih.gov/pubmed/25589173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0080-8
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