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Short, Enantioselective Total Synthesis of Chatancin()

An enantioselective total synthesis of the polycyclic diterpene chatancin (1), a potent PAF antagonist, is reported. Proceeding in seven steps from dihydrofarnesal, this synthetic route was designed to circumvent macrocyclization-based strategies to complex, cyclized cembranoids. The described synth...

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Publicado en:Angew Chem Int Ed Engl
Main Authors: Zhao, Yu-Ming, Maimone, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300267/
https://ncbi.nlm.nih.gov/pubmed/25470723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201410443
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