AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNaseII deficient mice

Innate immune PRRs sense nucleic acids from microbes and orchestrate cytokine production to resolve infection. Inappropriate recognition of host nucleic acids also results in autoimmune disease. Here we utilize a model of inflammation resulting from accrual of self DNA (DNase II(−/−) Ifnar(−/−)) to...

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Udgivet i:J Immunol
Main Authors: Baum, Rebecca, Sharma, Shruti, Carpenter, Susan, Li, Quan-Zhen, Busto, Patricia, Fitzgerald, Katherine A., Marshak-Rothstein, Ann, Gravallese, Ellen M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299698/
https://ncbi.nlm.nih.gov/pubmed/25548216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402573
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