IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo

Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its underlying mechanisms are poorly understood. We hypothesized that the epithelial cell–derived cytokine IL-33 plays a central role in exacerbation pathogenesis through augmentation of type 2 inflammation. Objectives: To...

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Bibliografiske detaljer
Udgivet i:Am J Respir Crit Care Med
Main Authors: Jackson, David J., Makrinioti, Heidi, Rana, Batika M. J., Shamji, Betty W. H., Trujillo-Torralbo, Maria-Belen, Footitt, Joseph, Jerico del-Rosario, Telcian, Aurica G., Nikonova, Alexandra, Zhu, Jie, Aniscenko, Julia, Gogsadze, Leila, Bakhsoliani, Eteri, Traub, Stephanie, Dhariwal, Jaideep, Porter, James, Hunt, Duncan, Hunt, Toby, Hunt, Trevor, Stanciu, Luminita A., Khaitov, Musa, Bartlett, Nathan W., Edwards, Michael R., Kon, Onn Min, Mallia, Patrick, Papadopoulos, Nikolaos G., Akdis, Cezmi A., Westwick, John, Edwards, Matthew J., Cousins, David J., Walton, Ross P., Johnston, Sebastian L.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299647/
https://ncbi.nlm.nih.gov/pubmed/25350863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201406-1039OC
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