IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo

Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its underlying mechanisms are poorly understood. We hypothesized that the epithelial cell–derived cytokine IL-33 plays a central role in exacerbation pathogenesis through augmentation of type 2 inflammation. Objectives: To...

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Bibliographic Details
Published in:Am J Respir Crit Care Med
Main Authors: Jackson, David J., Makrinioti, Heidi, Rana, Batika M. J., Shamji, Betty W. H., Trujillo-Torralbo, Maria-Belen, Footitt, Joseph, Jerico del-Rosario, Telcian, Aurica G., Nikonova, Alexandra, Zhu, Jie, Aniscenko, Julia, Gogsadze, Leila, Bakhsoliani, Eteri, Traub, Stephanie, Dhariwal, Jaideep, Porter, James, Hunt, Duncan, Hunt, Toby, Hunt, Trevor, Stanciu, Luminita A., Khaitov, Musa, Bartlett, Nathan W., Edwards, Michael R., Kon, Onn Min, Mallia, Patrick, Papadopoulos, Nikolaos G., Akdis, Cezmi A., Westwick, John, Edwards, Matthew J., Cousins, David J., Walton, Ross P., Johnston, Sebastian L.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299647/
https://ncbi.nlm.nih.gov/pubmed/25350863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201406-1039OC
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