IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo

Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its underlying mechanisms are poorly understood. We hypothesized that the epithelial cell–derived cytokine IL-33 plays a central role in exacerbation pathogenesis through augmentation of type 2 inflammation. Objectives: To...

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Опубликовано в: :Am J Respir Crit Care Med
Главные авторы: Jackson, David J., Makrinioti, Heidi, Rana, Batika M. J., Shamji, Betty W. H., Trujillo-Torralbo, Maria-Belen, Footitt, Joseph, Jerico del-Rosario, Telcian, Aurica G., Nikonova, Alexandra, Zhu, Jie, Aniscenko, Julia, Gogsadze, Leila, Bakhsoliani, Eteri, Traub, Stephanie, Dhariwal, Jaideep, Porter, James, Hunt, Duncan, Hunt, Toby, Hunt, Trevor, Stanciu, Luminita A., Khaitov, Musa, Bartlett, Nathan W., Edwards, Michael R., Kon, Onn Min, Mallia, Patrick, Papadopoulos, Nikolaos G., Akdis, Cezmi A., Westwick, John, Edwards, Matthew J., Cousins, David J., Walton, Ross P., Johnston, Sebastian L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299647/
https://ncbi.nlm.nih.gov/pubmed/25350863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201406-1039OC
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