Atorvastatin inhibits RhoC function and limits head and neck cancer metastasis

OBJECTIVE: RhoC oncogene is a well characterized marker of metastasis in a majority of invasive cancers, including HNSCC. Elevated RhoC expression has been found to be associated with distant metastasis. Statins are a class of drugs that are used to reduce cholesterol levels by inhibiting HMG-CoA re...

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Veröffentlicht in:Oral Oncol
Hauptverfasser: Islam, Mozaffarul, Sharma, Smita, Kumar, Bhavna, Teknos, Theodoros N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299638/
https://ncbi.nlm.nih.gov/pubmed/23648017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2013.04.003
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