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Down regulation of RhoC by microRNA-138 results in de-activation of FAK, Src and Erk(1/2) signaling pathway in head and neck squamous cell carcinoma

OBJECTIVE: RhoC a pro-metastatic oncogene is constitutively active in many head and neck squamous cell carcinomas. MicroRNA-138 which possesses a documented tumor suppressor function can bind to the 3′UTR of RhoC mRNA and inhibit its activity. We hypothesize that miR-138 can inhibit the function of...

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Publicado en:Oral Oncol
Main Authors: Islam, Mozaffarul, Datta, Jharna, Lang, James C., Teknos, Theodoros N.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296979/
https://ncbi.nlm.nih.gov/pubmed/24565984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2014.01.014
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