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Down regulation of RhoC by microRNA-138 results in de-activation of FAK, Src and Erk(1/2) signaling pathway in head and neck squamous cell carcinoma
OBJECTIVE: RhoC a pro-metastatic oncogene is constitutively active in many head and neck squamous cell carcinomas. MicroRNA-138 which possesses a documented tumor suppressor function can bind to the 3′UTR of RhoC mRNA and inhibit its activity. We hypothesize that miR-138 can inhibit the function of...
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| Publicat a: | Oral Oncol |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4296979/ https://ncbi.nlm.nih.gov/pubmed/24565984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2014.01.014 |
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