The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension

Rationale: Sphingosine kinases (SphKs) 1 and 2 regulate the synthesis of the bioactive sphingolipid sphingosine-1-phosphate (S1P), an important lipid mediator that promotes cell proliferation, migration, and angiogenesis. Objectives: We aimed to examine whether SphKs and their product, S1P, play a r...

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Dades bibliogràfiques
Publicat a:Am J Respir Crit Care Med
Autors principals: Chen, Jiwang, Tang, Haiyang, Sysol, Justin R., Moreno-Vinasco, Liliana, Shioura, Krystyna M., Chen, Tianji, Gorshkova, Irina, Wang, Lichun, Huang, Long Shuang, Usatyuk, Peter V., Sammani, Saad, Zhou, Guofei, Raj, J. Usha, Garcia, Joe G. N., Berdyshev, Evgeny, Yuan, Jason X.-J., Natarajan, Viswanathan, Machado, Roberto F.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2014
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299585/
https://ncbi.nlm.nih.gov/pubmed/25180446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201401-0121OC
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