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Binding of Thienamycin and Clavulanic Acid to the Penicillin-Binding Proteins of Escherichia coli K-12

Thienamycin and clavulanic acid are new β-lactam derivatives with structures markedly different from those of penicillins or cephalosporins. Both derivatives had the same general mode of action as typical β-lactam antibiotics since they bound to precisely the same proteins as [(14)C]benzylpenicillin...

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Bibliographic Details
Main Authors: Spratt, Brian G., Jobanputra, Vinay, Zimmermann, Willy
Format: Artigo
Language:Inglês
Published: 1977
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC429926/
https://ncbi.nlm.nih.gov/pubmed/334066
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