Biotransformation of Sisomicin to Gentamicin C(2b)

Sisomicin was transformed to gentamicin C(2b) by Micromonospora rhodorangea NRRL 5326. The mechanisms involved in the biotransformation are the 6′-N-methylation and the (4′-5′)-reduction. The progression of the methylation was followed by the isotope technique, but the reduction reaction was not mon...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Lee, B. K., Bailey, J. V., Condon, R. G., Marquez, J. A., Wagman, G. H., Weinstein, M. J.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1977
Materias:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429914/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/907326/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.12.3.335
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