Biotransformation of Sisomicin to Gentamicin C(2b)

Sisomicin was transformed to gentamicin C(2b) by Micromonospora rhodorangea NRRL 5326. The mechanisms involved in the biotransformation are the 6′-N-methylation and the (4′-5′)-reduction. The progression of the methylation was followed by the isotope technique, but the reduction reaction was not mon...

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Bibliographic Details
Main Authors: Lee, B. K., Bailey, J. V., Condon, R. G., Marquez, J. A., Wagman, G. H., Weinstein, M. J.
Format: Artigo
Language:Inglês
Published: 1977
Subjects:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC429914/
https://ncbi.nlm.nih.gov/pubmed/907326
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