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Insulin-like Growth Factor I Reduces Lipid Oxidation and Foam Cell Formation via Downregulation of 12/15-lipoxygenase
OBJECTIVE: We have shown that insulin-like growth factor I (IGF-1) infusion in Apoe(−/−) mice decreased atherosclerotic plaque size and plaque macrophage and lipid content suggesting that IGF-1 suppressed formation of macrophage-derived foam cells. Since 12/15-lipoxygenase (12/15-LOX) plays an impor...
Gorde:
| Argitaratua izan da: | Atherosclerosis |
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| Egile Nagusiak: | , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4298481/ https://ncbi.nlm.nih.gov/pubmed/25549319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2014.12.024 |
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