Insulin-like Growth Factor I Reduces Lipid Oxidation and Foam Cell Formation via Downregulation of 12/15-lipoxygenase

OBJECTIVE: We have shown that insulin-like growth factor I (IGF-1) infusion in Apoe(−/−) mice decreased atherosclerotic plaque size and plaque macrophage and lipid content suggesting that IGF-1 suppressed formation of macrophage-derived foam cells. Since 12/15-lipoxygenase (12/15-LOX) plays an impor...

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Vydáno v:Atherosclerosis
Hlavní autoři: Sukhanov, Sergiy, Snarski, Patricia, Vaughn, Charlotte, Lobelle-Rich, Patricia, Kim, Catherine, Higashi, Yusuke, Shai, Shaw-Yung, Delafontaine, Patrice
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298481/
https://ncbi.nlm.nih.gov/pubmed/25549319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2014.12.024
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