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Low circulating insulin-like growth factor I increases atherosclerosis in ApoE-deficient mice

Some clinical studies have suggested that lower IGF-I levels may be associated with an increased risk of ischemic heart disease. We generated atherosclerosis-prone apolipoprotein E-deficient (ApoE(−/−)) mice with 6T alleles (6T/ApoE(−/−) mice) with a 20% decline in circulating IGF-I and fed these mi...

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Bibliografische gegevens
Hoofdauteurs: Shai, Shaw-Yung, Sukhanov, Sergiy, Higashi, Yusuke, Vaughn, Charlotte, Rosen, Clifford J., Delafontaine, Patrice
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094094/
https://ncbi.nlm.nih.gov/pubmed/21335474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01081.2010
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