The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling

Primary clear cell renal cell carcinoma (ccRCC) genetic heterogeneity may lead to an underestimation of the mutational burden detected from a single site evaluation. We sought to characterize the extent of clonal branching involving key tumor suppressor mutations in primary ccRCC and determine if ge...

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Bibliografiske detaljer
Udgivet i:Cancer Med
Main Authors: Sankin, Alexander, Hakimi, Abraham A, Mikkilineni, Nina, Ostrovnaya, Irina, Silk, Mikhail T, Liang, Yupu, Mano, Roy, Chevinsky, Michael, Motzer, Robert J, Solomon, Stephen B, Cheng, Emily H, Durack, Jeremy C, Coleman, Jonathan A, Russo, Paul, Hsieh, James J
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
Fag:
Clinical Cancer Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298374/
https://ncbi.nlm.nih.gov/pubmed/25124064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.293
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