Cutting Edge: Epigenetic Regulation of Foxp3 Defines a Stable Population of CD4(+) Regulatory T Cells in Tumors from Mice and Humans

CD4(+) regulatory T cells (Tregs) are critical for maintaining self-tolerance and function to prevent autoimmune disease. High densities of intratumoral Tregs are generally associated with poor patient prognosis, a correlation attributed to their broad immune-suppressive features. Two major populati...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Waight, Jeremy D., Takai, Shinji, Marelli, Bo, Qin, Guozhong, Hance, Kenneth W., Zhang, Dong, Tighe, Robert, Lan, Yan, Lo, Kin-Ming, Sabzevari, Helen, Hofmeister, Robert, Wilson, Nicholas S.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2015
Assuntos:
Cutting Edge
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298129/
https://ncbi.nlm.nih.gov/pubmed/25548231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402725
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