Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

Triggering receptor expressed on myeloid cells (TREM)-1 is an orphan receptor implicated in innate immune activation. Inhibition of TREM-1 reduces sepsis in mouse models, suggesting a role for it in immune responses triggered by bacteria. However, the absence of an identified ligand has hampered a f...

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Publicado en:J Immunol
Autores principales: Read, Christine B., Kuijper, Joseph L., Hjorth, Siv A., Heipel, Mark D., Tang, Xiaoting, Fleetwood, Andrew J., Dantzler, Jeffrey L., Grell, Susanne N., Kastrup, Jesper, Wang, Camilla, Brandt, Cameron S., Hansen, Anker J., Wagtmann, Nicolai R., Xu, Wenfeng, Stennicke, Vibeke W.
Formato: Artigo
Lenguaje:Inglês
Publicado: AAI 2015
Materias:
Cutting Edge
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319313/
https://ncbi.nlm.nih.gov/pubmed/25595774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402303
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