Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells

Therapeutic application of human embryonic stem cells (hESCs) requires precise control over their differentiation. However, spontaneous differentiation is prevalent, and growth factors induce multiple cell types; e.g., the mesoderm inducer BMP4 generates both mesoderm and trophoblast. Here we identi...

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Publicado no:Stem Cell Reports
Main Authors: Kurek, Dorota, Neagu, Alex, Tastemel, Melodi, Tüysüz, Nesrin, Lehmann, Johannes, van de Werken, Harmen J.G., Philipsen, Sjaak, van der Linden, Reinier, Maas, Alex, van IJcken, Wilfred F.J., Drukker, Micha, ten Berge, Derk
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297870/
https://ncbi.nlm.nih.gov/pubmed/25544567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.11.007
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