Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells

Therapeutic application of human embryonic stem cells (hESCs) requires precise control over their differentiation. However, spontaneous differentiation is prevalent, and growth factors induce multiple cell types; e.g., the mesoderm inducer BMP4 generates both mesoderm and trophoblast. Here we identi...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Kurek, Dorota, Neagu, Alex, Tastemel, Melodi, Tüysüz, Nesrin, Lehmann, Johannes, van de Werken, Harmen J.G., Philipsen, Sjaak, van der Linden, Reinier, Maas, Alex, van IJcken, Wilfred F.J., Drukker, Micha, ten Berge, Derk
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297870/
https://ncbi.nlm.nih.gov/pubmed/25544567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.11.007
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