Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells

Summary: Therapeutic application of human embryonic stem cells (hESCs) requires precise control over their differentiation. However, spontaneous differentiation is prevalent, and growth factors induce multiple cell types; e.g., the mesoderm inducer BMP4 generates both mesoderm and trophoblast. Here...

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Main Authors: Dorota Kurek, Alex Neagu, Melodi Tastemel, Nesrin Tüysüz, Johannes Lehmann, Harmen J.G. van de Werken, Sjaak Philipsen, Reinier van der Linden, Alex Maas, Wilfred F.J. van IJcken, Micha Drukker, Derk ten Berge
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-01-01
Serier:Stem Cell Reports
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213671114003579
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