Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires

Celiac disease is caused by intolerance to cereal gluten proteins, and HLA-DQ molecules are involved in the disease pathogenesis by presentation of gluten peptides to CD4(+) T cells. The α- or β-chain sharing HLA molecules DQ2.5, DQ2.2, and DQ7.5 display different risks for the disease. It was recen...

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Bibliographische Detailangaben
Veröffentlicht in:Immunogenetics
Hauptverfasser: Bergseng, Elin, Dørum, Siri, Arntzen, Magnus Ø., Nielsen, Morten, Nygård, Ståle, Buus, Søren, de Souza, Gustavo A., Sollid, Ludvig M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2014
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297300/
https://ncbi.nlm.nih.gov/pubmed/25502872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00251-014-0819-9
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