A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys

Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed tha...

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Gepubliceerd in:Cell Host Microbe
Hoofdauteurs: Douglas, Alexander D., Baldeviano, G. Christian, Lucas, Carmen M., Lugo-Roman, Luis A., Crosnier, Cécile, Bartholdson, S. Josefin, Diouf, Ababacar, Miura, Kazutoyo, Lambert, Lynn E., Ventocilla, Julio A., Leiva, Karina P., Milne, Kathryn H., Illingworth, Joseph J., Spencer, Alexandra J., Hjerrild, Kathryn A., Alanine, Daniel G.W., Turner, Alison V., Moorhead, Jeromy T., Edgel, Kimberly A., Wu, Yimin, Long, Carole A., Wright, Gavin J., Lescano, Andrés G., Draper, Simon J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297294/
https://ncbi.nlm.nih.gov/pubmed/25590760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.11.017
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