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ΔNP63α Transcriptionally Activates Chemokine Receptor 4 (CXCR4) Expression to Regulate Breast Cancer Stem Cell Activity and Chemotaxis

ΔNP63α, the predominant TP63 isoform expressed in diverse epithelial tissues, including the mammary gland is required for the preservation of stem cells and has been implicated in tumorigenesis and metastasis. Despite data characterizing ΔNP63α as a master regulator of stem cell activity, identifica...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: DeCastro, Andrew J., Cherukuri, Pratima, Balboni, Amanda, DiRenzo, James
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297234/
https://ncbi.nlm.nih.gov/pubmed/25376609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0194
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