Phosphorylation of ΔNp63α via a Novel TGFβ/ALK5 Signaling Mechanism Mediates the Anti-Clonogenic Effects of TGFβ

Genetic analysis of TP63 implicates ΔNp63 isoforms in preservation of replicative capacity and cellular lifespan within adult stem cells. ΔNp63α is also an oncogene and survival factor that mediates therapeutic resistance in squamous carcinomas. These diverse activities are the result of genetic and...

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Detaylı Bibliyografya
Asıl Yazarlar: Cherukuri, Pratima, DeCastro, Andrew J., Balboni, Amanda L., Downey, Sondra L., Liu, Jennifer Y., Hutchinson, Justine A., DiRenzo, James
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500343/
https://ncbi.nlm.nih.gov/pubmed/23166821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050066
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