ΔNp63α Mediated Activation of Bone Morphogenetic Protein Signaling Governs Stem Cell Activity and Plasticity in Normal and Malignant Mammary Epithelial Cells

Genetic analysis of TP63indicates that ΔNp63 isoforms are required for preservation of regenerative stasis within diverse epithelial tissues. In squamous carcinomas, TP63 is commonly amplified, and ΔNp63α confers a potent survival advantage. Genome-wide occupancy studies demonstrate that ΔNp63 promo...

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Hlavní autoři: Balboni, Amanda L., Hutchinson, Justine A., DeCastro, Andrew J., Cherukuri, Pratima, Liby, Karen, Sporn, Michael B., Schwartz, Gary N., Wells, Wendy A., Sempere, Lorenzo F., Yu, Paul B., DiRenzo, James
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739305/
https://ncbi.nlm.nih.gov/pubmed/23243027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2862
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