Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

BACKGROUND: Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in several tissues, including heart. Because some pathological conditions such as ische...

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Vydáno v:Cell Commun Signal
Hlavní autoři: Aguiar, Carla J, Rocha-Franco, João A, Sousa, Pedro A, Santos, Anderson K, Ladeira, Marina, Rocha-Resende, Cibele, Ladeira, Luiz O, Resende, Rodrigo R, Botoni, Fernando A, Barrouin Melo, Marcos, Lima, Cristiano X, Carballido, José M, Cunha, Thiago M, Menezes, Gustavo B, Guatimosim, Silvia, Leite, M Fatima
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296677/
https://ncbi.nlm.nih.gov/pubmed/25539979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0078-2
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